Consequences of Motor Copy Number on the Intracellular Transport of Kinesin-1-Driven Lipid Droplets

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Consequences of Motor Copy Number on the Intracellular Transport of Kinesin-1-Driven Lipid Droplets

The microtubule motor kinesin-1 plays central roles in intracellular transport. It has been widely assumed that many cellular cargos are moved by multiple kinesins and that cargos with more motors move faster and for longer distances; concrete evidence, however, is sparse. Here we rigorously test these notions using lipid droplets in Drosophila embryos. We first employ antibody inhibition, gene...

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Disruptions in microtubule motor transport are associated with a variety of neurodegenerative diseases. Post-translational modification of the cargo-binding domain of the light and heavy chains of kinesin has been shown to regulate transport, but less is known about how modifications of the motor domain affect transport. Here we report on the effects of phosphorylation of a mammalian kinesin mo...

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ژورنال

عنوان ژورنال: Cell

سال: 2008

ISSN: 0092-8674

DOI: 10.1016/j.cell.2008.10.021